HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1505056Generated: October 31, 2026
Methyl vinyl sulfone → 5-Bromo-2-(2-(methylsulfonyl)ethyl)-1,2,3,4-tetrahydroisoquinoline
https://huagongshe.com/reaction/1505056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl vinyl sulfone | HCID 19354 | — |
| Reactant | 5-Bromo-1,2,3,4-tetrahydroisoquinoline | HCID 12823199 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-2-(2-(methylsulfonyl)ethyl)-1,2,3,4-tetrahydroisoquinoline | HCID 58318051 | — |
Reaction Steps
A mixture containing 5-bromo-1,2,3,4-tetrahydroisoquinoline (212 mg, 1 mmol) and methylsulfonylethene (106 mg, 1 mmol) in dichloromethane is stirred at 35° C. for 14 hours. The solution is concentrated to afford 5-bromo-2-(2-(methylsulfonyl)ethyl)-1,2,3,4-tetrahydroisoquinoline as a brown oil (LC-MS m/z: 318.1 (M+1)) which is used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09216964B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-09959647adb34a67b0e7092d40152b8e |
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| Source note | uspto-grants-2015_12 |
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