p,p'-Dimethoxybenzhydryl alcohol → 4-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

HRID 1505128Notes

Reaction equation

HRID 1505128 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7](O)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[SH:19][C:20]1C=C[C:23]([B:26]([OH:28])[OH:27])=[CH:22][CH:21]=1>CC(O)=O>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7]([C:21]2[CH:22]=[C:23]([B:26]([OH:28])[OH:27])[S:19][CH:20]=2)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 69768p,p'-Dimethoxybenzhydryl alcoholHCID 44318944-Mercaptophenylboronic acid

Product 1

HCID 671206874-(4,4'-Dimethoxybenzhydryl)-thiophenyl boronic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

4,4′-Dimethoxybenzhydrol (2.7 g, 11 mmol) and 4-mercaptophenylboronic acid (1.54 g, 10 mmol) were dissolved in 20 mL AcOH and heated at 60° C. for 1 h. Solvent was evaporated and the residue was dried under high vacuum. This material was used without further purification.

Workup

  1. customSolvent was evaporated
  2. customthe residue was dried under high vacuum
  3. customThis material was used without further purification

Sources & evidence

ORD record
ord-618295768668417fba5aa145302f249c
Source dataset
uspto-grants-2015_12
Patent number
US09216969B2

Reaction notes

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