Water → HCID 67449947, compound

Participants

Reaction Conditions

Reaction Steps

The nitrile 26b (2.15 g, 8.33 mmol) solubilized in Et2O (20 mL) was added in small portion to a mixture of LiAlH4 (0.63 g, 2 mol eq) in Et2O (25 mL) stirred at 0° C. Then the mixture was stirred at room temperature overnight. The excess of LiAlH4 was decomposed by water addition at 0° C., the solid formed was filtered, washed with Et2O and the filtrate was separated. The organic phase was anhydrified over Na2SO4 and evaporated to dryness to obtain 27b as yellow oil (1.48 g, 5.64 mmol, 67% Yield) used without further purifications.

Provenance & Evidence