1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene → HCID 67218075, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-azido-2-methyl-benzoic acid methyl ester (made in analogy to methods described in, for example, Journal of Organic Chemistry, 2006, 71(15), 5822-5825) (820 mg, 3.4 mmol) and 1,3-dichloro-5-(1-trifluoromethyl-vinyl)-benzene (preparation described in, for example, EP 1,731,512) (500 mg, 2.6 mmol) in toluene (20 ml) was heated at 130° C. for 48 hours. The reaction mixture was concentrated and the residue purified by column chromatography on silica gel (eluent: 3% v/v ethyl acetate in hexane) to give 4-[4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-[1,2,3]triazol-1-yl]-2-methyl-benzoic acid methyl ester as a gummy oil (200 mg).

Provenance & Evidence