Water → 7-bromo-N-hydroxybenzo[1,2,5]thiadiazole-4-carbimidoyl chloride

Participants

Reaction Steps

To a solution of 7-bromo-benzo[1,2,5]thiadiazole-4-carbaldehyde oxime (Example 5.4) (16.65 g) in dimethylformamide (150 ml) was added N-chlorosuccinimide (“NCS”) (10.34 g). The reaction mixture stirred at ambient temperature for 16 hours. Water (750 ml) was added to the reaction mixture and the solids were isolated by filtration to obtain 7-bromo-N-hydroxy-benzo[1,2,5]thiadiazole-4-carbimidoyl chloride (15.77 g) as a yellow solid which was used without further purification.

Provenance & Evidence