Bromine → Methyl 4-bromo-3-hydroxy-2-nitrobenzoate

HRID 1505249Notes

Reaction equation

HRID 1505249 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:5]=1[N+:11]([O-:13])=[O:12].[Br:15]Br>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([Br:15])=[C:6]([OH:10])[C:5]=1[N+:11]([O-:13])=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 13659833Methyl 3-hydroxy-2-nitrobenzoate

Product 1

HCID 58497911Methyl 4-bromo-3-hydroxy-2-nitrobenzoateYield 42.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 3-hydroxy-2-nitrobenzoic acid methyl ester (Example 6.1) (11 g) in chloroform (220 ml) was added dropwise bromine (18.7 g). The reaction mixture was heated at reflux for 16 hours. The reaction mixture was allowed to cool to ambient temperature and the reaction quenched by addition of aqueous sodium metabisulfite (22 g in 100 ml water) and the mixture was stirred for 15 minutes. The phases were separated and the organic phase was washed with brine, dried over sodium sulfate and concentrated. The residue was crystallized from diethyl ether/heptane to give 4-bromo-3-hydroxy-2-nitro-benzoic acid methyl ester (6.6 g). 1H-NMR (400 MHz, CDCl3): 9.92 (s, 1H), 7.84 (d, 1H), 7.09 (d, 1H), 3.93 (s, 3H) ppm.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. customthe reaction quenched by addition of aqueous sodium metabisulfite (22 g in 100 ml water)
  4. customThe phases were separated
  5. washthe organic phase was washed with brine
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated
  8. customThe residue was crystallized from diethyl ether/heptane

Sources & evidence

ORD record
ord-8ba7282b742b454faa1f7bc6b037598d
Source dataset
uspto-grants-2015_12
Patent number
US09216973B2

Reaction notes

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