Trifluoroacetic acid → HCID 58497947, compound

Participants

Reaction Steps

To a stirred solution of 5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid tert-butyl ester (Example 9.5) (1.0 g) in dichloromethane (2 ml) was added trifluoroacetic acid (2 ml) and the reaction mixture was stirred at ambient temperature for 4 hours. The reaction mixture was concentrated to give a solid which was washed with cyclohexane to give 5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid (0.76 g). 1H-NMR (DMSO, 400 MHz): 8.95 (m, 2H), 8.20 (d, 1H), 7.90 (d, 1H), 7.65-7.80 (m, 5H), 4.50 (q, 2H).

Provenance & Evidence