Water → HCID 58497922, compound

Participants

Reaction Steps

To a solution of dibromoformaldoxime (6.23 g, Tetrahedron Lett., 1984, 487) in ethyl acetate (150 ml) was added 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (6.3 g, prepared according to WO 2005/085216) and sodium bicarbonate (9.5 g). The reaction was stirred at room temperature for 96 h. Water was added, then the two layers were then separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers were dried over sodium sulfate and concentrated to afford a white solid (6.23 g). 1H-NMR (CDCl3, 400 MHz): 7.47-7.43 (m, 3H), 3.95 (d, 1H), 3.58 (d, 1H)

Provenance & Evidence