HuagongsheHuagongshe Chemistry Print Report · For research reference only
N1-(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)-D-alaninamide → (5R)-5-methyl-3-(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N1-(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)-D-alaninamide | HCID 67235021 | — |
| Reactant | HCID 67235532 | HCID 67235532 | — |
| Product | (5R)-5-methyl-3-(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione | HCID 53241720 | — |
Reaction Steps
The title compound was made in a similar fashion to the preparation of Example 7 replacing N1-(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)-D-alaninamide with N1-(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-alaninamide (Intermediate 56, 118 mg) to afford the title compound (78 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216967B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-cafcfa74aa9346f6be93e0ae24c89e21 |
| Source note | uspto-grants-2015_12 |