HCID 67235595, compound → HCID 53241721, compound

HRID 1505411Notes

Reaction equation

HRID 1505411 reaction equation
CC(C1C=[C:6]([O:10]C2N=CC(NC(=O)[C@@H](C)N)=CC=2)C=CC=1)C.[CH3:23][C:24]1[C:29]([O:30][CH3:31])=[CH:28][CH:27]=[CH:26][C:25]=1[O:32][C:33]1[N:38]=[CH:37][C:36]([NH:39][C:40](=[O:44])[C@@H:41]([CH3:43])[NH2:42])=[CH:35][CH:34]=1>>[CH3:43][C@H:41]1[NH:42][C:6](=[O:10])[N:39]([C:36]2[CH:37]=[N:38][C:33]([O:32][C:25]3[CH:26]=[CH:27][CH:28]=[C:29]([O:30][CH3:31])[C:24]=3[CH3:23])=[CH:34][CH:35]=2)[C:40]1=[O:44]

Participants

3

Reactant 2

HCID 67235595HCID 67235595, compound2×HCID 67235751HCID 67235751, compound

Product 1

HCID 53241721HCID 53241721, compound

Procedure

The title compound was made in a similar fashion to the preparation of Example 9 replacing N1-(6-{[3-(1-methylethyl)phenyl]oxy}-3-pyridinyl)-D-alaninamide with N1-(6-{[2-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-D-alaninamide (Intermediate 63, 200 mg) to afford the title compound (184 mg).

Sources & evidence

ORD record
ord-08f8957ca83a45c7819f8039f2f9f55b
Source dataset
uspto-grants-2015_12
Patent number
US09216967B2

Reaction notes

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