Hydrazine hydrate (1:1) → HCID 178509230, compound

Participants

Reaction Steps

A suspension of 38.5 g (245.93 mmol) of 2-chloro-5-fluoronicotinonitrile was initially charged in 1,2-ethanediol (380 ml), and hydrazine hydrate (119.6 ml) was then added. With stirring, the mixture was heated at reflux for 4 h. On cooling, the product precipitated out. Water (380 ml) was added to the crystals, and the mixture was stirred at RT for 10 min. The suspension was then filtered off with suction through a frit and washed with water (200 ml) and with −10° C.-cold THF (200 ml). Drying under high vacuum over phosphorus pentoxide.

Provenance & Evidence