1-(Bromomethyl)-2,3-difluoro-benzene → HCID 66656116, compound

HRID 1505459Notes

Reaction equation

HRID 1505459 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.[F:11][C:12]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14]Br>>[F:11][C:12]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][N:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[C:2]([I:1])=[N:3]1

Participants

3

Reactant 2

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 178506575HCID 178506575, compound

Product 1

HCID 66656116HCID 66656116, compound

Procedure

Analogously to the synthesis of Example 7A, 54.00 g (215.98 mmol) of 3-iodo-1H-pyrazolo[3,4-b]pyridine (synthesis described in WO 2006/130673 Example 4) were reacted with 50.18 g (237.578) of 2,3-difluorobenzyl bromide. Ice-water was added to the crude product, the mixture was filtered off with suction and the precipitate was washed with isopropanol and pentane and then dried under high vacuum. This gave 73.00 g of the title compound (85% of theory).

Workup

  1. filtrationthe mixture was filtered off with suction
  2. washthe precipitate was washed with isopropanol and pentane
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-3c517f4a803c4d73a5d675900a0cc69f
Source dataset
uspto-grants-2015_12
Patent number
US09216978B2

Reaction notes

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