HCID 53669213, compound → tert-Butyl (3-amino-2,6-difluorophenyl)carbamate

HRID 1505486Notes

Reaction equation

HRID 1505486 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([N+:15]([O-])=O)[C:9]=1[F:18])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([NH2:15])[C:9]=1[F:18])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 53669213HCID 53669213, compound

Product 1

HCID 70700579tert-Butyl (3-amino-2,6-difluorophenyl)carbamateYield 86%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

After dissolving the tert-butyl-2,6-difluoro-3-nitrophenylcarbamate (1 g, 3.6 mmol) prepared at Step 2 in methanol solvent, palladium carbon (100 mg) was added and stirred under hydrogen pressure for 15 hours. After completing the reaction, filtering through celite, vacuum concentrating, and refining by means of column chromatography, 0.76 mg of the target compound, tert-butyl-3-amino-2,6-difluorophenylcarbamate (percentage yield: 86%), was obtained.

Workup

  1. customthe reaction
  2. filtrationfiltering through celite, vacuum
  3. concentrationconcentrating

Sources & evidence

ORD record
ord-2872033f5edb4d5cbd8b392ac5a36589
Source dataset
uspto-grants-2015_12
Patent number
US09216981B2

Reaction notes

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