Ammonia → HCID 90405643, compound

HRID 1505657Notes

Reaction equation

HRID 1505657 reaction equation
[CH3:1][O:2][C:3]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[C:6]([C:13]([O:15]C)=O)[NH:7]2.[NH3:17]>CO>[CH3:1][O:2][C:3]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[C:6]([C:13]([NH2:17])=[O:15])[NH:7]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11424532770729-07-2

Product 1

HCID 90405643HCID 90405643, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

80 mg of methyl 4-methoxy-5-methyl-1H-indole-2-carboxylate (0.39 mmol) was heated at 80 degrees in a sealed tube with 1 mL of 7M ammonia in methanol. After one week reaction the solvent evaporated to produce 79 mg of 4-methoxy-5-methyl-1H-indole-2-carboxamide that was used without purification in the next step.

Workup

  1. customAfter one week reaction the solvent
  2. customevaporated

Sources & evidence

ORD record
ord-7981d7b370454baf9dc58b1830e07515
Source dataset
uspto-grants-2015_12
Patent number
US09216993B2

Reaction notes

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