HCID 89924329, compound → HCID 178484568, compound

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Reaction Steps

4-(4-{2-[3-(1-Methyl-1H-pyrazol-4-yl)-phenyl]-pyrimidin-5-yl}-pyrazol-1-yl)-cyclohexanecarboxylic acid dimethylamide (example 121; 165 mg; 0.33 mmol) was suspended in DMF and filtered to give the title compound as a white solid (50 mg; 20%). 1H NMR (300 MHz, DMSO) δ 9.16 (s, 2H), 8.53 (t, J=1.6 Hz, 1H), 8.49 (s, 1H), 8.26 (s, 1H), 8.24-8.18 (m, 1H), 8.13 (s, 1H), 7.92 (d, J=0.7 Hz, 1H), 7.74-7.67 (m, 1H), 7.51 (t, J=7.8 Hz, 1H), 4.32-4.16 (m, 1H), 3.89 (s, 3H), 3.05 (s, 3H), 2.83 (s, 3H), 2.77-2.63 (m, 1H), 2.20-2.06 (m, 2H), 1.97-1.77 (m, 4H), 1.67-1.48 (m, 2H). HPLC (Chiralpak IC, EtOH:THF 90:10): Rt 6.91 min (purity 98.4%); MS (ESI+): 456.4.

Provenance & Evidence