Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1505725Generated: November 1, 2026

Thionyl Chloride → 6-phenethyl-N-phenyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxamide

https://huagongshe.com/reaction/1505725

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant6-hydroxy-6-phenethyl-N-phenyl-7-(trifluoromethyl)-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxamideHCID 86691994—
SolventPyridineHCID 1049—
Product6-phenethyl-N-phenyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxamideHCID 86691995—

Reaction Steps

The 6-hydroxy-6-phenethyl-N-phenyl-7-(trifluoromethyl)-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxamide was further processed with thionyl chloride and pyridine as described in Example 1, above to yield 6-phenethyl-N-phenyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxamide (5 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09216998B2
Source datasetuspto-grants-2015_12
ORD IDord-54abc5c103384408876e879736eb4131
Source noteuspto-grants-2015_12