HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-phenethyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboximidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (NZ)-N-[[(2-methylpropan-2-yl)oxycarbonylamino]-[6-(2-phenylethyl)-5-(trifluoromethyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-11-yl]methylidene]carbamate | HCID 140613434 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-phenethyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboximidamide | HCID 86691997 | 51.8% |
Reaction Steps
A solution of Z-tert-butyl(((tert-butoxycarbonyl)imino)(6-phenethyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indol-2(1H)-yl)methyl)carbamate (74 mg, 0.13 mmol) in CH2Cl2 (5 mL) was treated with 4M HCl in 1,4-dioxane (12 mL) and the resulting mixture was stirred at room temperature overnight. Evaporation of the solvent and trituration with diethyl ether yielded 6-phenethyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboximidamide (26 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216998B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-69e69117d990487b966ef799d2cbf464 |
| Source note | uspto-grants-2015_12 |