HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1505733Generated: October 31, 2026
Diisopropylethylamine → HCID 86692004, compound
https://huagongshe.com/reaction/1505733
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Reactant | 6-Phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole | HCID 86691988 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86692004 | HCID 86692004 | 81.9% |
Reaction Steps
A mixture of 6-phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole (prepared as described in Example 2 above, 100 mg, 0.26 mmol), 2-bromoethoxy t-butyl(dimethyl)silane (63 mg, 0.26 mmol) and diisopropylethylamine (0.09 mL, 0.53 mmol) in THF was heated at 80° C. for 5 h. The solvent was evaporated to yield 2-(2-((tert-butyldimethylsilyl)oxy)ethyl-6-phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole (107 mg, MS m/z 503 (MH+)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09216998B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-8e100d4628324d0e8b85f9a93bacf95f |
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| Source note | uspto-grants-2015_12 |
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