Hydrochloric Acid → HCID 86692005, compound

Participants

Reaction Steps

To a mixture of 2-(2-((tert-butyldimethylsilyl)oxy)ethyl-6-phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole (107 mg, 0.21 mmol) in THF was added conc. HCl (2 mL) at 0° C. and the resulting mixture stirred for 1 h. Purification by reverse-phase chromatography (25→90% CH3CN—H2O-TFA) yielded 2-(6-phenethyl-7-(trifluoromethyl)-3,4-dihydro-[1,4]diazepino[6,7,1-hi]indol-2(1H)-yl)ethanol (50 mg).

Provenance & Evidence