Methanesulfonyl chloride → HCID 86692006, compound

Participants

Reaction Steps

A solution of 6-phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole (prepared as described in Example 2 above, 53 mg, 0.14 mmol), methanesulfonyl chloride (16 mg, 0.14 mmol) and diisopropylethylamine (0.072 mL, 0.42 mmol) in CH2Cl2 (3 mL) was stirred overnight. The solvent was evaporated under reduced pressure and the resulting residue purified by trituration from methanol-diethyl ether to 2-(methylsulfonyl)-6-phenethyl-7-(trifluoromethyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole (43 mg).

Provenance & Evidence