HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dihydro-2H-1,4-benzoxazine → HCID 86692007, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dihydro-2H-1,4-benzoxazine | HCID 585096 | — |
| Reactant | HCID 15651912 | HCID 15651912 | — |
| Solvent | 1,1,1,3,3,3-Hexafluoro-2-propanol | HCID 13529 | — |
| Product | HCID 86692007 | HCID 86692007 | — |
Reaction Steps
A solution of 2-ethoxy-3-phenethyl-2-(trifluoromethyl)oxirane (340 mg, 1.3 mmol) and 3,4-dihydro-2H-benzo[b][1,4]oxazine (177 mg, 1.3 mmol) in hexafluoroisopropanol was stirred at room temperature overnight. The solvent was evaporated and the residue purified by reverse-phase HPLC (CH3CN/0.1% trifluoroacetic acid) to yield 5-phenethyl-6-(trifluoromethyl)-2,3,5,6-tetrahydro-[1,4]oxazino[2,3,4-hi]indol-6-ol as a solid (MS m/z 350 MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216998B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-3bbf3a1c86294e18bc2848fbbd7f9440 |
| Source note | uspto-grants-2015_12 |