HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Methyl 2-amino-5-bromo-4-chlorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 4-chloroanthranilate | HCID 80001 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 2-amino-5-bromo-4-chlorobenzoate | HCID 53436879 | 93% |
Reaction Steps
To a solution of methyl 2-amino-4-chlorobenzoate (20.0 g, 108 mmol) in DMF (200 mL) was added N-bromosuccinimide (19.2 g, 108 mmol) in one portion and stirred overnight at room temperature. The resulting solids were filtered off and dissolved in toluene, dried with Na2SO4, and concentrated to give methyl 2-amino-5-bromo-4-chlorobenzoate (26.47 g, 93%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09217004B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-ade5447312274da48b7a0fbe00c901fc |
| Source note | uspto-grants-2015_12 |