Formaldehyde → HCID 71532469, compound

Participants

Reaction Steps

To a solution of N-(3-chloro-2-methylphenyl)-2-[(2S)-pyrrolidin-2-yl]-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxamide (Example 71) (25 mg) in MeOH (0.4 mL), was added 38% aqueous formaldehyde solution (7.2 μL), and the mixture was stirred at room temperature overnight. To the mixture was added 2-picoline borane (10 mg), it was stirred for 3 hours, and the solvent was removed under reduced pressure. The residue was purified on column chromatography to obtain the titled compound (11 mg) as white powder.

Provenance & Evidence