HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Diaminobenzoic acid methyl ester → Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Diaminobenzoic acid methyl ester | HCID 571825 | — |
| Reactant | Ethyl beta-amino-beta-ethoxyacrylate hydrochloride | HCID 53395434 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 2-(2-ethoxy-2-oxoethyl)-1H-benzimidazole-4-carboxylate | HCID 90229347 | 106.2% |
Reaction Steps
A solution of methyl 2,3-diaminobenzoate (680 mg) and ethyl 3-amino-3-ethoxyacrylate hydrochloride (880 mg) in EtOH (12 mL) was stirred at 60° C. for 2 hours. EtOH was removed under reduced pressure, and the residue was purified on column chromatography to obtain the titled compound (1.14 g) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216968B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-1b90bd2e121847489527c70af599b16e |
| Source note | uspto-grants-2015_12 |