HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylethanolamine → 4-(2-Pyridinylmethoxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylethanolamine | HCID 7497 | — |
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | Methanesulfonic acid pyridin-2-ylmethyl ester | HCID 22417657 | — |
| Reactant | 2-Chloro-4-[(4-fluorophenoxy)methyl]pyridine | HCID 62299799 | — |
| Reactant | 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one | HCID 68431283 | — |
| Product | 4-(2-Pyridinylmethoxy)-1-{4-[2-(diethylamino)ethoxy]phenyl}-1H-pyridin-2-one | HCID 68431797 | — |
Reaction Steps
Steps (1) and (2) of Example 28 were repeated except that 4-fluorobenzyl bromide used in Example 28 was replaced with 2-methanesulfonyloxymethylpyridine, and successively Example 12 was repeated except that so obtained compound was used in place of 4-benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one in Step (3) and 2-(1-pyrrolidine)ethanol was replaced with 2-(diethylamino)ethanol, to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732456B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-346479f217a54dc0be427131770c50f8 |
| Source note | uspto-grants-2010_06 |