Sodium hydride → 6-[4-(1-Ethyl-piperidin-4-yloxy)-pyridin-3-yl]-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4',3'-d]pyrrole

HRID 1506074Notes

Reaction equation

HRID 1506074 reaction equation
[H-].[Na+].[CH2:3]([N:5]1[CH2:10][CH2:9][CH:8]([OH:11])[CH2:7][CH2:6]1)[CH3:4].Cl[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][C:14]=1[C:19]1[N:27]=[CH:26][C:25]2[NH:24][C:23]3[N:28]=[CH:29][C:30]([C:32]4[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=4)=[CH:31][C:22]=3[C:21]=2[CH:20]=1>CN(C=O)C>[CH2:3]([N:5]1[CH2:10][CH2:9][CH:8]([O:11][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[C:19]2[N:27]=[CH:26][C:25]3[NH:24][C:23]4[N:28]=[CH:29][C:30]([C:32]5[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=5)=[CH:31][C:22]=4[C:21]=3[CH:20]=2)[CH2:7][CH2:6]1)[CH3:4]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 770561-Ethylpiperidin-4-olHCID 670275236-(4-Chloro-pyridin-3-yl)-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Product 1

HCID 445457526-[4-(1-Ethyl-piperidin-4-yloxy)-pyridin-3-yl]-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4',3'-d]pyrroleYield 13%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Sodium hydride (60% dispersion in mineral oil, 0.133 g, 3.32 mmol) was added to a solution of 1-ethyl-piperidin-4-ol (0.306 g, 2.37 mmol) in DMF (5 mL) and the reaction mixture was stirred at ambient temperature for 45 minutes. 6-(4-Chloro-pyridin-3-yl)-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole (0.121 g, 0.474 mmol) was added and the reaction mixture was heated at 80° C. for 5 h. The material was partitioned between water and ethyl acetate. The solid suspended in the aqueous layer was removed by filtration then the aqueous layer was separated, adsorbed onto HM-N and purified by flash chromatography (silica, 12 g column, ISCO, 0-10% (2N ammonia in methanol) in DCM). The resultant residue was triturated with ethyl acetate and cyclohexane to afford the title compound as a yellow solid (28 mg, 13%). 1H NMR (MeOD, 400 MHz): 8.97 (d, J=1.1 Hz, 1H), 8.83-8.80 (m, 2H), 8.73 (s, 1H), 8.60 (d, J=1.1 Hz, 1H); 8.43 (d, J=5.9 Hz, 1H), 8.11 (s, 1H), 7.97 (d, J=0.8 Hz, 1H), 7.28 (d, J=6.0 Hz, 1H), 3.98 (s, 3H), 2.65-2.54 (m, 2H), 2.53-2.43 (m, 2H), 2.39 (q, J=7.3 Hz, 2H), 2.13-2.03 (m, 2H), 1.97-1.86 (m, 2H), 1.02 (t, J=7.2 Hz, 3H). LCMS (Method A): RT=4.0 min, M+H+=454.

Workup

  1. temperaturethe reaction mixture was heated at 80° C. for 5 h
  2. customThe material was partitioned between water and ethyl acetate
  3. customwas removed by filtration
  4. customthe aqueous layer was separated
  5. custompurified by flash chromatography (silica, 12 g column, ISCO, 0-10% (2N ammonia in methanol) in DCM)
  6. customThe resultant residue was triturated with ethyl acetate and cyclohexane

Sources & evidence

ORD record
ord-182766cc78154a37a1f2f7d0ef7b4836
Source dataset
uspto-grants-2015_12
Patent number
US09216980B2

Reaction notes

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