HCID 71141839, compound → HCID 71264118, compound

HRID 1506175Notes

Reaction equation

HRID 1506175 reaction equation
C[Si](C)(C)CCOC[N:7]1[C:15]2[N:14]=[CH:13][N:12]3[CH:16]=[N:17][C:18]([CH:19]4[CH2:24][CH2:23][N:22]([CH2:25][C:26]5[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[CH:28][CH:27]=5)[CH2:21][CH2:20]4)=[C:11]3[C:10]=2[CH:9]=[CH:8]1.C[Si](C)(C)CCOCN1C2N=CN3C=NC(C4CCCN(C(OCC5C=CC=CC=5)=O)C4)=C3C=2C=C1>>[C:18]1([CH:19]2[CH2:24][CH2:23][N:22]([CH2:25][C:26]3[CH:27]=[CH:28][C:29]([C:30]#[N:31])=[CH:32][CH:33]=3)[CH2:21][CH2:20]2)[N:17]=[CH:16][N:12]2[C:11]=1[C:10]1[CH:9]=[CH:8][NH:7][C:15]=1[N:14]=[CH:13]2

Participants

3

Reactant 2

HCID 71141839HCID 71141839, compoundHCID 71258462HCID 71258462, compound

Product 1

HCID 71264118HCID 71264118, compoundYield 4%

Procedure

The reactions in Synthetic Examplea 3 were carried out in substantially the same manners except that 4-{[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-imidazo[1,5-c]pyrrolo[3,2-e]pyrimidin-1-yl)piperidin-1-yl]methyl}benzonitrile obtained in Reference Synthetic Examplea 97 was used instead of benzyl 3-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-imidazo[1,5-c]pyrrolo[3,2-e]pyrimidin-1-yl)piperidine-1-carboxylate to give the title compound as a brown solid (1.3 mg, yield 4%).

Workup

  1. customobtained in Reference Synthetic Examplea 97

Sources & evidence

ORD record
ord-d10633a6d5f14c0884a6e8ff80b76ad6
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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