HCID 136341326, compound → HCID 178511023, compound

HRID 1506187Notes

Reaction equation

HRID 1506187 reaction equation
[C:1]1([C@H:13]2[CH2:18][CH2:17][C@H:16]([CH:19]=O)[CH2:15][CH2:14]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2.[C:21]1(C2CCC(=O)CC2)[N:22]=NN2[C:29]=1C1C=CNC=1N=C2>>[C:1]1([C@H:13]2[CH2:18][CH2:17][C@H:16](/[CH:19]=[CH:29]/[C:21]#[N:22])[CH2:15][CH2:14]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2

Participants

3

Reactant 2

HCID 136341326HCID 136341326, compoundHCID 178520935HCID 178520935, compound

Product 1

HCID 178511023HCID 178511023, compoundYield 7%

Procedure

The reactions in Synthetic Examplea 434 were carried out in substantially the same manners except that trans-4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexanecarbaldehyde (30.0 mg, 0.111 mmol) obtained in Synthetic Examplea 78 was used instead of 4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexanone to give the title compound as a colorless solid (3.60 mg, yield 7%).

Workup

  1. customobtained in Synthetic Examplea 78

Sources & evidence

ORD record
ord-34f90107f7da4c2f93c395d189c689e1
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

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