HCID 136341328, compound → HCID 178511024, compound

HRID 1506188Notes

Reaction equation

HRID 1506188 reaction equation
[C:1]1([C@H:13]2[CH2:18][CH2:17][C@H:16](/[CH:19]=[CH:20]/[C:21]#[N:22])[CH2:15][CH2:14]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2.C1(C2CCC(=CC(OCC)=O)CC2)N=NN2C=1C1C=CNC=1N=C2>>[C:1]1([C@H:13]2[CH2:14][CH2:15][C@H:16]([CH2:19][CH2:20][C:21]#[N:22])[CH2:17][CH2:18]2)[N:2]=[N:3][N:4]2[C:9]=1[C:8]1[CH:10]=[CH:11][NH:12][C:7]=1[N:6]=[CH:5]2

Participants

3

Reactant 2

HCID 136341328HCID 136341328, compoundHCID 178511023HCID 178511023, compound

Product 1

HCID 178511024HCID 178511024, compoundYield 72%

Procedure

The reactions in Synthetic Examplea 438 were carried out in substantially the same manners except that (E)-3-[trans-4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexyl]acrylonitrile obtained in Synthetic Examplea 440 was used instead of ethyl 2-[4-(7H-pyrrolo[3,2-e][1,2,3]triazolo[1,5-c]pyrimidin-1-yl)cyclohexylidene]acetate to give the title compound as a colorless solid (7.30 mg, yield 72%).

Workup

  1. customobtained in Synthetic Examplea 440

Sources & evidence

ORD record
ord-0f82b086bdc1443eb57dec7c629dd220
Source dataset
uspto-grants-2015_12
Patent number
US09216999B2

Reaction notes

Loading…