1H-Pyrrolo(2,3-b)pyridine → HCID 178526243, compound

Participants

Reaction Conditions

Reaction Steps

m-Chloroperbenzoic acid (25 wt % water content, 12.7 g, 55.2 mmol) in ethyl acetate (30 mL) was gradually added dropwise to 1H-pyrrolo[2,3-b]pyridine (5.14 g, 43.5 mmol) in ethyl acetate (45 mL) cooled to 0° C., and the reaction mixture was stirred at room temperature for one day and then stirred with m-chloroperbenzoic acid (25 wt % water content, 3.93 g, 17.1 mmol) in ethyl acetate (4 mL) at room temperature for 4 hours. The reaction mixture was cooled with ice and filtered, and the resulting solid was purified by silica gel column chromatography (silica gel NH type manufactured by Fuji Silysia Chemical Ltd.: chloroform/methanol=10/1 (v/v)) to give the title compound as a yellow solid (4.95 g, yield 85%).

Provenance & Evidence