Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

2,3-Diamino-5-bromopyridine (4.10 g, 21.8 mmol) in formic acid (25 mL) was stirred at 100° C. for 4 hours. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure, and the resulting residue was mixed with water and adjusted to pH 8 or above with saturated aqueous sodium hydrogen carbonate. The precipitated solid was collected by filtration, washed with water and chloroform and dried under reduced pressure to give the title compound as a dark brown solid (4.13 g, yield 96%).

1. concentrationconcentrated under reduced pressure
2. additionthe resulting residue was mixed with water
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with water and chloroform
5. customdried under reduced pressure

ORD record

ord-7fe1f8ffecf14747854f74b16f5897a9

Source dataset

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09216999B2