反应详情

Ethyl 4-(4-chlorophenyl)-4-methylpent-2-enoate (Intermediate I-9B, 0.24 g, 0.950 mmol) was dissolved in methanol (20 mL) and treated with 10% Pd/C (0.06 g, 0.282 mmol) under a hydrogen atmosphere for 1 hr using a balloon. The reaction mixture was filtered through CELITE®. The filtrate was concentrated under reduced pressure to yield ethyl 4-(4-chlorophenyl)-4-methylpentanoate in quantitative yield. LC/MS M+1=255.11.

1. filtrationThe reaction mixture was filtered through CELITE®
2. concentrationThe filtrate was concentrated under reduced pressure