3-(4-(4-Chlorophenyl)cyclohexyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole → 1-(3-(4-(4-Chlorophenyl)cyclohexyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethane-1,2-diol

HRID 1506377Notes

Reaction equation

HRID 1506377 reaction equation
FC1C=CC(C2(CC[C:16]3[O:20][N:19]=[C:18]4[C:21]5[C:26]([CH2:27][CH2:28][C:17]=34)=[CH:25][C:24]([CH:29]([OH:32])[CH2:30][OH:31])=[CH:23][CH:22]=5)CCCCC2)=CC=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2[CH2:45][CH2:44][CH:43](C3ON=C4C5C(CCC=34)=CC(C=C)=CC=5)[CH2:42][CH2:41]2)=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2[CH2:45][CH2:44][CH:43]([C:16]3[O:20][N:19]=[C:18]4[C:21]5[C:26]([CH2:27][CH2:28][C:17]=34)=[CH:25][C:24]([CH:29]([OH:32])[CH2:30][OH:31])=[CH:23][CH:22]=5)[CH2:42][CH2:41]2)=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 671689533-(4-(4-Chlorophenyl)cyclohexyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 671718521-(3-(2-(1-(4-Fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethane-1,2-diol

Product 1

HCID 671720721-(3-(4-(4-Chlorophenyl)cyclohexyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethane-1,2-diol

Procedure

This compound was prepared according to the general procedure described for Preparation 26B employing 3-(4-(4-chlorophenyl)cyclohexyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole (Preparation 27B) as the starting material. LC/MS M+1=424.19.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-edfbd5a1430a45f0ad07f3731759d3ba
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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