HCID 58374151, compound → HCID 67167881, compound

HRID 1506396Notes

Reaction equation

HRID 1506396 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH:8]([NH:14][C:15](C1ON=C(C3C=CC=CC=3)C=1C(F)(F)F)=[O:16])[CH2:7][CH2:6]2.[C:32]1([C:38]2[O:42][N:41]=[C:40](C(O)=O)[C:39]=2[C:46]([F:49])([F:48])[F:47])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH:8]([NH:14][C:15]([C:40]1[C:39]([C:46]([F:47])([F:49])[F:48])=[C:38]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[O:42][N:41]=1)=[O:16])[CH2:7][CH2:6]2

Participants

3

Reactant 2

HCID 58374151HCID 58374151, compound2×HCID 67169548HCID 67169548, compound

Product 1

HCID 67167881HCID 67167881, compound

Procedure

The titled compound was prepared using the experimental protocol described for Preparation 43A employing 5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxylic acid (Step D of Intermediate 5). 1H NMR (400 MHz, CDCl3) δ ppm 8.04 (1H, d, J=8.80 Hz), 7.85 (1H, d, J=5.28 Hz), 7.70 (2H, d, J=7.48 Hz), 7.52-7.62 (3H, m), 6.88 (1H, dd, J=8.80, 2.42 Hz), 6.74 (1H, d, J=2.20 Hz), 4.78 (1H, ddd, J=13.53, 4.95, 4.84 Hz), 3.89 (3H, s), 3.29 (1H, ddd, J=17.11, 12.93, 4.29 Hz), 2.93-3.08 (2H, m), 1.97-2.10 (1H, m).

Sources & evidence

ORD record
ord-062c0c4fe84b40329663380858704833
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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