Trifluoroacetic acid → HCID 67169171, compound

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Reaction Steps

A solution of 7-(2,2-dimethyl-1,3-dioxolan-4-yl)-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazole (Preparation 61B, 0.042 g, 0.087 mmol) in TFA (1.00 ml, 13.0 mmol) was left standing at room temperature for 45 min. The TFA was removed under reduced pressure, and the residue was diluted with dichloromethane, washed with a saturated aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded 1-(3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-4H-chromeno[4,3-c]isoxazol-7-yl)ethane-1,2-diol (0.039 g, 0.088 mmol, 100% yield) as an off-white solid. The product had an HPLC ret. time=3.00 min.−Column: Chromolith SpeedROD 4.6×50 mm (4 min.); Solvent A=10% MeOH, 90% H2O, 0.1% TFA; Solvent B=90% MeOH, 10% H2O, 0.1% TFA. LC/MS M+1=444.9.

Provenance & Evidence