Hydroxyamine hydrochloride → HCID 87294738, compound

Participants

Reaction Conditions

Reaction Steps

To 6-methoxy-7-methyl-3,4-dihydronaphthalen-1(2H)-one (0.500 g, 2.63 mmol) in methanol (10 mL) were sequentially added hydroxylamine hydrochloride (0.292 g, 4.21 mmol) and sodium acetate (0.345 g, 4.21 mmol) at room temperature. The reaction mixture was heated at 60° C. for 2 h. The reaction mixture was concentrated under vacuum. The residue was dissolved in 25 mL ethyl acetate, transferred to a separating funnel and washed with water (2×10 mL). The ethyl acetate layer was dried over sodium sulfate and concentrated to give (E)-6-methoxy-7-methyl-3,4-dihydronaphthalen-1(2H)-one oxime as viscous orange-colored liquid (0.498 g, 2.43 mmol, 92%). The product had an HPLC ret. time=3.10 min (condition B). LC/MS M+1=206.0.

Provenance & Evidence