3-(3,4-Diethoxyphenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole → 3-(3,4-Diethoxyphenyl)-7-(oxiran-2-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

HRID 1506477Notes

Reaction equation

HRID 1506477 reaction equation
[O:1]1[CH2:3][CH:2]1[C:4]1[CH:5]=[C:6]2[C:29](=[CH:30][CH:31]=1)[C:10]1=[N:11][O:12][C:13]([C:14]3C(C(F)(F)F)=C(C4C=CC=CC=4)ON=3)=[C:9]1[CH2:8][CH2:7]2.[CH2:32]([O:34][C:35]1[CH:36]=[C:37](C2ON=C3C4C(CCC=23)=CC(C=C)=CC=4)C=[CH:39][C:40]=1[O:41][CH2:42][CH3:43])[CH3:33]>>[CH2:42]([O:41][C:40]1[CH:39]=[C:14]([C:13]2[O:12][N:11]=[C:10]3[C:29]4[C:6]([CH2:7][CH2:8][C:9]=23)=[CH:5][C:4]([CH:2]2[CH2:3][O:1]2)=[CH:31][CH:30]=4)[CH:37]=[CH:36][C:35]=1[O:34][CH2:32][CH3:33])[CH3:43]

Participants

3

Reactant 2

HCID 671702973-(3,4-Diethoxyphenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazoleHCID 866698787-(Oxiran-2-yl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

Product 1

HCID 866699223-(3,4-Diethoxyphenyl)-7-(oxiran-2-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

Procedure

This compound was prepared according to the procedure described for Preparation 13A, employing 70 mgs of 3-(3,4-diethoxyphenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole (80A). Yield: 80 mgs (25%); LC/MS M+1=378.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-759385932cb8478bb9f25330f8632a54
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

Loading…