3-Phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)isoxazole → 2-Pentyl-7-vinyl-4,5-dihydronaphtho[2,1-d]thiazole

HRID 1506491Notes

Reaction equation

HRID 1506491 reaction equation
[C:1]1([C:7]2[C:11](C(F)(F)F)=[C:10]([C:16]3[S:17][C:18]4[C:28]5[C:23](=[CH:24][C:25]([CH:29]=[CH2:30])=[CH:26][CH:27]=5)[CH2:22][CH2:21][C:19]=4[N:20]=3)ON=2)C=CC=C[CH:2]=1.BrC1C=C2C(=CC=1)C1SC(CCCCC)=NC=1CC2>>[CH2:10]([C:16]1[S:17][C:18]2[C:28]3[C:23](=[CH:24][C:25]([CH:29]=[CH2:30])=[CH:26][CH:27]=3)[CH2:22][CH2:21][C:19]=2[N:20]=1)[CH2:11][CH2:7][CH2:1][CH3:2]

Participants

3

Reactant 2

HCID 671705843-Phenyl-4-(trifluoromethyl)-5-(7-vinyl-4,5-dihydronaphtho[2,1-d]thiazol-2-yl)isoxazoleHCID 681820787-Bromo-2-pentyl-4,5-dihydronaphtho[2,1-d]thiazole

Product 1

HCID 671716022-Pentyl-7-vinyl-4,5-dihydronaphtho[2,1-d]thiazole

Procedure

This compound was prepared according to the procedure described for Preparation 82E, employing 270 mgs of 7-bromo-2-pentyl-4,5-dihydronaphtho[2,1-d]thiazole (Preparation 86B). Yield: (193 mgs, 85%). LC/MS M+1=337.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-d00440bb097d4d4894a8f8c2991f6c1b
Source dataset
uspto-grants-2015_12
Patent number
US09216972B2

Reaction notes

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