HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1506503Generated: October 30, 2026
Diethyl 2-((tert-butoxycarbonyl)amino)malonate → Diethyl 2-(tert-butoxycarbonylamino)-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)malonate
https://huagongshe.com/reaction/1506503
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl 2-((tert-butoxycarbonyl)amino)malonate | HCID 382219 | — |
| Reactant | Ethyl 2-(diphenylmethyleneamino)-4-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate | HCID 86669931 | — |
| Product | Diethyl 2-(tert-butoxycarbonylamino)-2-(2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethyl)malonate | HCID 68182047 | — |
Reaction Steps
The titled compound was prepared using the experimental protocol described for Preparation 91A employing diethyl 2-(tert-butoxycarbonylamino)malonate as a starting material. The reaction was heated at 70° C. for 7 hr. The compound had an LC/MS [M-Boc]+1=584.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09216972B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-80a6909c10c6430f923a98283820f61d |
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| Source note | uspto-grants-2015_12 |
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