HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-phenyl-4-(trifluoromethyl)isothiazole-5-carboxylate → 3-(3-Phenyl-4-(trifluoromethyl)isothiazol-5-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-phenyl-4-(trifluoromethyl)isothiazole-5-carboxylate | HCID 58374139 | — |
| Reactant | 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole | HCID 67170420 | — |
| Reactant | (NE)-N-(6-ethenyl-3,4-dihydro-2H-naphthalen-1-ylidene)hydroxylamine | HCID 121012766 | — |
| Product | 3-(3-Phenyl-4-(trifluoromethyl)isothiazol-5-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole | HCID 67171496 | — |
Reaction Steps
The titled compound was prepared using the experimental protocol described for Preparation 89A employing 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (Intermediate 1) and methyl 3-phenyl-4-(trifluoromethyl)isothiazole-5-carboxylate (Preparation 103E) as starting materials. The compound had an HPLC retention time=4.25 min. (condition C); LC/MS M+1=424.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216972B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-9dbb24818afc458f800aaf7964953320 |
| Source note | uspto-grants-2015_12 |