反应详情

The titled compound was prepared using the experimental protocols described for Preparation 91A, and Example 93 employing 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole (89A) as a starting material. The compound had an HPLC retention time=3.03 min. (condition C); LC/MS M+1=483.3; 1H NMR (400 MHz, MeOD) δ ppm 8.14 (1H, s), 7.85 (1H, d, J=7.7 Hz), 7.53-7.65 (5H, m), 7.30 (1H, s), 7.28 (1H, d, J=7.9 Hz), 3.67 (1H, d, J=11.5 Hz), 3.56 (1H, d, J=11.5 Hz), 3.03 (2H, t, J=6.9 Hz), 2.90 (2H, t, J=6.9 Hz), 2.66-2.81 (2H, m), 1.86-2.07 (2H, m), 1.37 (3H, s).