HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-phenyl-4-(trifluoromethyl)isothiazole-3-carboxylate → 3-(5-Phenyl-4-(trifluoromethyl)isothiazol-3-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-phenyl-4-(trifluoromethyl)isothiazole-3-carboxylate | HCID 67168409 | — |
| Reactant | 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole | HCID 67170420 | — |
| Reactant | 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime | HCID 86669866 | — |
| Product | 3-(5-Phenyl-4-(trifluoromethyl)isothiazol-3-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole | HCID 67171650 | — |
Reaction Steps
The titled compound was prepared using the experimental protocol described for Preparation 89A employing 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (Intermediate I-1) and methyl 5-phenyl-4-(trifluoromethyl)isothiazole-3-carboxylate (Preparation 105B) as starting materials. The compound had an HPLC retention time=4.30 min. (condition C); LC/MS M+1=424.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216972B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2608c901a09b4ed790312e0d80e1ce40 |
| Source note | uspto-grants-2015_12 |