HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-cyano-3-phenylisothiazole-5-carboxylate → 3-Phenyl-5-(7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)isothiazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-cyano-3-phenylisothiazole-5-carboxylate | HCID 67169144 | — |
| Reactant | 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole | HCID 67170420 | — |
| Reactant | (NE)-N-(6-ethenyl-3,4-dihydro-2H-naphthalen-1-ylidene)hydroxylamine | HCID 121012766 | — |
| Product | 3-Phenyl-5-(7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazol-3-yl)isothiazole-4-carbonitrile | HCID 67170084 | — |
Reaction Steps
The titled compound was prepared using the experimental protocol described for Preparation 89A employing 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (Intermediate 1) and methyl 4-cyano-3-phenylisothiazole-5-carboxylate (Preparation 106A) as starting materials. The compound had an HPLC retention time=4.30 min. (condition C); LC/MS M+1=424.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09216972B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-4c3cacf371734854b7b35eb08849fd37 |
| Source note | uspto-grants-2015_12 |