Methyl 4-cyclohexyl-3-(trifluoromethyl)benzoate → 3-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Participants

Role	Name	HCID	Charge
Reactant	Methyl 4-cyclohexyl-3-(trifluoromethyl)benzoate	HCID 67169319	—
Reactant	3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole	HCID 67170420	—
Reactant	(NE)-N-(6-ethenyl-3,4-dihydro-2H-naphthalen-1-ylidene)hydroxylamine	HCID 121012766	—
Product	3-(4-Cyclohexyl-3-(trifluoromethyl)phenyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole	HCID 67170984	—

Reaction Steps

The titled compound was prepared using the experimental protocol described for Preparation 89A employing 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (Intermediate 1) and methyl 4-cyclohexyl-3-(trifluoromethyl)benzoate (Preparation 118C) as starting materials. The compound had an HPLC retention time=4.83 min. (condition C); LC/MS M+1=424.3.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09216972B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-bdfd09115e7d4cb19f6cd91536432ef3
Source note	uspto-grants-2015_12