HCID 67169668, compound → HCID 67171061, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)propanoate (Preparation 134C, isomer 1, 85 mg, 0.175 mmol) was dissolved in 4 N hydrochloric acid in dioxane (1 mL). The reaction mixture stirred at 60° C. for 48 h before it was concentrated to yield 2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)propanoic acid (80 mg, 0.17 mmol, 97% yield): LC/MS M+1=472.03. Isomer 2: Methyl 2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)propanoate (Preparation 134C, isomer 2, 83 mg, 0.171 mmol) was dissolved in 4 N hydrochloric acid in dioxane (1 mL). The reaction mixture was stirred at 60° C. for 48 h before it was concentrated to yield 2-hydroxy-2-(3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)propanoic acid (80 mg, 0.17 mmol, 99% yield): LC/MS M+1=472.03.

Provenance & Evidence