HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1506583Generated: October 25, 2026
Hydrochloric Acid → 4-[4-(Cyclohexylacetyl)-1,3-thiazol-2-yl]piperidinium chloride
https://huagongshe.com/reaction/1506583
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate | HCID 67468980 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[4-(Cyclohexylacetyl)-1,3-thiazol-2-yl]piperidinium chloride | HCID 67468256 | — |
Reaction Steps
Under argon and at 0° C., a solution of hydrogen chloride in dioxane (4M, 1 ml) was added to a solution of tert-butyl 4-[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (5.0 g) in diethyl ether (1 ml). The mixture was stirred at 0° C. and then slowly warmed to room temperature. After stirring overnight, excess acid and the solvent were removed under reduced pressure. This gave 4-[4-(cyclohexylacetyl)-1,3-thiazol-2-yl]piperidinium chloride (315 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09220266B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-3f2055d5462d4336990478066d4e4032 |
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| Source note | uspto-grants-2015_12 |
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