HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoroindole-3-acetic acid → (S)-2-(5-fluoro-1H-indol-3-yl)-N-(2-phenyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoroindole-3-acetic acid | HCID 96750 | — |
| Reactant | (S)-2-phenyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine | HCID 2512349 | — |
| Reactant | N-[(1S)-2-(3,5-difluorophenyl)-1-[1-(4-methoxyphenyl)imidazol-2-yl]ethyl]-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl]acetamide | HCID 90281246 | — |
| Product | (S)-2-(5-fluoro-1H-indol-3-yl)-N-(2-phenyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl)acetamide | HCID 90281308 | — |
Reaction Steps
The title compound was prepared according to the method presented for the synthesis of compound 5F of Example 5 utilizing 18A and 2-(5-fluoro-1H-indol-3-yl)acetic acid. 1H NMR (400 MHz, DMSO) δ 10.92 (s, 1H), 8.90 (d, J=8.0 Hz, 1H), 7.94 (m, 2H), 7.68-7.39 (m, 3H), 7.37-7.06 (m, 8H), 6.85 (td, J=9.2, 2.5 Hz, 1H), 5.34 (dd, J=13.8, 9.2 Hz, 1H), 3.46-3.20 (m, 4H); MS (m/z) 441.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09220710B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-4161806084de433f9ae20d257838069d |
| Source note | uspto-grants-2015_12 |