tert-Butylsulfinamide, (S)-(-)- → (NE)-N-[[5-(4-chlorophenyl)-1,3-oxazol-4-yl]methylidene]-2-methylpropane-2-sulfinamide

HRID 1506662Notes

Reaction equation

HRID 1506662 reaction equation
COC1C=CC(N2C=CN=C2C=[N:15][S@@:16]([C:18]([CH3:21])([CH3:20])[CH3:19])=[O:17])=CC=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:33][CH:32]=[N:31][C:30]=2[CH:34]=O)=[CH:25][CH:24]=1.CC([S@@](N)=O)(C)C>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[O:33][CH:32]=[N:31][C:30]=2/[CH:34]=[N:15]/[S:16]([C:18]([CH3:21])([CH3:20])[CH3:19])=[O:17])=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 11355477tert-Butylsulfinamide, (S)-(-)-HCID 153155355-(4-Chlorophenyl)oxazole-4-carbaldehydeHCID 90281518(R)-N-((1-(4-methoxyphenyl)-1H-imidazol-2-yl)methylene)-2-methylpropane-2-sulfinamide

Product 1

HCID 90280296(NE)-N-[[5-(4-chlorophenyl)-1,3-oxazol-4-yl]methylidene]-2-methylpropane-2-sulfinamide

Procedure

The title compound was prepared according to the method presented for the synthesis of compound 5B of Example 5 utilizing 33D and (S)-2-methylpropane-2-sulfinamide. MS (m/z) 311.2 [M+H]+.

Sources & evidence

ORD record
ord-4cdfe6f6639740f69feeb0fc1c198d05
Source dataset
uspto-grants-2015_12
Patent number
US09220710B2

Reaction notes

Loading…