huagongshe.com
HRID1506666

反应详情

EQUATION

反应方程式

HRID 1506666 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)Cc1c[nH]c2ccc(O)cc12
HCID1826

(5-Hydroxy-1H-indol-3-yl)acetic acid

C10H9NO3

结构：Cl.NC(Cc1cc(F)cc(F)c1)c1ncoc1-c1ccc(Cl)cc1
HCID90280171

未命名化合物

结构：COc1ccc(-n2ccnc2[C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2CCCC3)cc1
HCID90281246

未命名化合物

PRODUCTS

生成物

1
结构：O=C(Cc1c[nH]c2ccc(O)cc12)NC(Cc1cc(F)cc(F)c1)c1ncoc1-c1ccc(Cl)cc1
HCID90281254

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the method presented for the synthesis of compound 5F of Example 5 utilizing 33G and 2-(5-hydroxy-1H-indol-3-yl)acetic acid. 1H NMR (400 MHz, DMSO) δ 10.46 (s, 1H), 8.63 (d, J=8.0 Hz, 1H), 8.45 (s, 1H), 7.59 (d, J=8.4 Hz, 2H), 7.43 (d, J=8.5 Hz, 2H), 7.07 (d, J=8.6 Hz, 1H), 7.00-6.84 (m, 2H), 6.79 (d, J=8.4 Hz, 3H), 6.55 (d, J=8.7 Hz, 1H), 5.28 (q, J=7.8 Hz, 1H), 3.39 (s, 2H), 3.10 (m, 2H). MS (m/z) 508.1 [M+H]+.