Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | N-(benzyloxycarbonyl)-4-(mesyloxy)butylamine | HCID 11141145 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70982893 | HCID 70982893 | 65.8% |
Reaction Steps
To a pressure vessel was added 4-(benzyloxycarbonylamino)butyl methanesulfonate (330 mg, 1.10 mmol) and pyrrolidine (234 mg, 3.3 mmol) in THF. The reaction was heated to 100° C., stirred overnight, cooled to 20-25° C., and concentrated. The crude concentrate was purified by Biotage column chromatography to give benzyl 4-(pyrrolidin-1-yl)butylcarbamate (200 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09221760B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-a6e1e4e716004fd9bae0b55d6f38032d |
|---|
| Source note | uspto-grants-2015_12 |
|---|
